Description
Light yellow Cryst
Basic Attributes
CAS No：1072-97-5
Molecular Formula ：C5H5BrN2
Molecular Mass ：173.01
Exact Mass ：171.963608
PSA ：38.9 A^2
LogP ：1.2
EINECS ：214-019-9
InChIKeys ：WGOLHUGPTDEKCF-UHFFFAOYSA-N
H-bond Acceptor ：2
H-bond Donor ：1
SP3 ：0.00
RBN ：0
Characteristics
Appearance ：White to beige Crystalline Powder
Density ：1.6065 (rough estimate)
Melting Point ：133-138 °C(lit.)
Bolling Point ：230.9±20.0 °C(Predicted)
Flash Point ：93.4±21.8 °C
Refractive Index ：1.5182 (estimate)
Solubility ：Soluble in methanol, chloroform, ethyl acetate. Slightly soluble in water.
Storage Condition ：Store below +30°C.
BRN ：108737
Safety Information
Hazard Class ：IRRITANT
HS Code ：29333999
UN No. ：UN 2811 6.1/PG 3
WGK_Germany ：2
Risk Code ：22-36/37/38
Safety Instructions ：26-36
Dangerous Mark ：Xn,Xi
P Code ：P261-P301 + P310-P305 + P351 + P338
Hazard Statements ：H301-H315-H319-H335
Hazard Note ：Irritant
Product Usage
2-Amino-5-bromopyridine is an organic synthesis intermediate and pharmaceutical intermediate. It can be used in the laboratory research and development process and the chemical medicine research and development process. It can be used as a raw material for the preparation of drugs and fine chemicals.
Production Methods
General procedure: Nitrobenzene (0.6mmol), 5wtpercent Pd/C (0.5mmol percent, 0.003mmol), H2O (10 equiv, 6.0mmol), B2(OH)4 (3.3 equiv, 2.0mmol), and CH3CN (1.0mL) were added in a 10mL tube. The reaction mixture was stirred at 50°C for 24h. When the reaction was complete monitored by TLC, the mixture was cooled to room temperature. Water (5mL) was added, and extracted with EtOAc (3×5mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give aniline 2a (55mg, 99percent).To the mixture of pyridin-2-ylamine (10.0 g, 106 mmol) in acetone (200 mL), was added NBS (22.6 g, 127 mmol) portionwise at 0°C. The mixture was warmed to room temperature and stirred overnight. Solvent was evaporated in vacuum. The residue was purified by silica gel column (DCM/MeOH, 20/1) to afford 18 g (yield: 98percent) of 5-bromo-pyridin-2- ylamine as yellow solid. [00589] 1H NMR (DMSO-d6): δ = 7.94 (IH, d), 7.61 (IH, dd), 6.43 (IH, d), 6.10 (2H, brs).4.5.4 14.8 g (89.4 mmol) of potassium bromate was dissolved in the succinimide aqueous solution recovered in the previous step.In the condition of 25 °C, stirring, 17.5 mL of 50percent sulfuric acid aqueous solution was added dropwise.
http://www.echemi.com/products/pid_Seven7060-2-amino-5-bromopyridine.html
Uploaded 3 years ago
![Description
Light yellow Cryst
Basic Attributes
CAS No：1072-97-5
Molecular Formula ：C5H5BrN2
Molecular Mass ：173.01
Exact Mass ：171.963608
PSA ：38.9 A^2
LogP ：1.2
EINECS ：214-019-9
InChIKeys ：WGOLHUGPTDEKCF-UHFFFAOYSA-N
H-bond Acceptor ：2
H-bond Donor ：1
SP3 ：0.00
RBN ：0
Characteristics
Appearance ：White to beige Crystalline Powder
Density ：1.6065 (rough estimate)
Melting Point ：133-138 °C(lit.)
Bolling Point ：230.9±20.0 °C(Predicted)
Flash Point ：93.4±21.8 °C
Refractive Index ：1.5182 (estimate)
Solubility ：Soluble in methanol, chloroform, ethyl acetate. Slightly soluble in water.
Storage Condition ：Store below +30°C.
BRN ：108737
Safety Information
Hazard Class ：IRRITANT
HS Code ：29333999
UN No. ：UN 2811 6.1/PG 3
WGK_Germany ：2
Risk Code ：22-36/37/38
Safety Instructions ：26-36
Dangerous Mark ：Xn,Xi
P Code ：P261-P301 + P310-P305 + P351 + P338
Hazard Statements ：H301-H315-H319-H335
Hazard Note ：Irritant
Product Usage
2-Amino-5-bromopyridine is an organic synthesis intermediate and pharmaceutical intermediate. It can be used in the laboratory research and development process and the chemical medicine research and development process. It can be used as a raw material for the preparation of drugs and fine chemicals.
Production Methods
General procedure: Nitrobenzene (0.6mmol), 5wtpercent Pd/C (0.5mmol percent, 0.003mmol), H2O (10 equiv, 6.0mmol), B2(OH)4 (3.3 equiv, 2.0mmol), and CH3CN (1.0mL) were added in a 10mL tube. The reaction mixture was stirred at 50°C for 24h. When the reaction was complete monitored by TLC, the mixture was cooled to room temperature. Water (5mL) was added, and extracted with EtOAc (3×5mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give aniline 2a (55mg, 99percent).To the mixture of pyridin-2-ylamine (10.0 g, 106 mmol) in acetone (200 mL), was added NBS (22.6 g, 127 mmol) portionwise at 0°C. The mixture was warmed to room temperature and stirred overnight. Solvent was evaporated in vacuum. The residue was purified by silica gel column (DCM/MeOH, 20/1) to afford 18 g (yield: 98percent) of 5-bromo-pyridin-2- ylamine as yellow solid. [00589] 1H NMR (DMSO-d6): δ = 7.94 (IH, d), 7.61 (IH, dd), 6.43 (IH, d), 6.10 (2H, brs).4.5.4 14.8 g (89.4 mmol) of potassium bromate was dissolved in the succinimide aqueous solution recovered in the previous step.In the condition of 25 °C, stirring, 17.5 mL of 50percent sulfuric acid aqueous solution was added dropwise.
http://www.echemi.com/products/pid_Seven7060-2-amino-5-bromopyridine.html](https://iili.io/d15M9S.png)
