Regorafenib is used to treat colon and rectal cancer (cancer that begins in the large intestine or the rectum) that has spread to other parts of the body in people who have not been treated successfully with certain other medications. It is also used to treat gastrointestinal stromal tumors (GIST; a type of tumor that grows in the stomach, intestine [bowel], or esophagus [tube that connects the throat with the stomach]) in people who were not treated successfully with certain other medications.

How should this medicine be used? 
Regorafenib comes as a tablet to take by mouth. It is usually taken with a low-fat meal (containing under 600 calories and less than 30% of calories from fat) once a day for 3 weeks and then skipped for 1 week. This treatment period is called a cycle, and the cycle may be repeated for as long as your doctor recommends. Take regorafenib at the same time every day.

What special precautions should I follow? 
Before taking regorafenib, tell your doctor and pharmacist if you are allergic to regorafenib, any other medications, or any of the ingredients in regorafenib tablets. Ask your pharmacist for a list of the ingredients.

What should I do if I forget a dose?
 If you miss a dose of regorafenib, take the missed dose as soon as you remember it on that day. Do not take two doses on the same day to make up for a missed one.

What side effects can this medication cause? 
Regorafenib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: tiredness weakness loss of appetite diarrhea swelling, pain, and redness of the lining of your mouth or throat weight loss hoarseness or other change in the sound of your voice.

Above content source:  https://www.911globalmeds.com/info/208-1-Regorafenib-Stivarga-Resihance-Nublexa-Medication-Patient-Information-In-English.pdf

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